Calcium Hopantenate Hemihydrate is a calcium salt form of hopantenic acid (pantogam), a derivative of pantothenic acid (Vitamin B5). It is primarily used for its nootropic (cognitive-enhancing) and neuroprotective properties.
Medical and Pharmacological Applications:
| Application | Description |
| Nootropic Agent | Used to improve cognitive functions like memory, attention, and mental performance, especially in neurological disorders. |
| Neuroprotective | Protects brain cells from damage caused by stress, toxins, or metabolic disturbances. |
| Treatment of ADHD in Children | Used to improve attention, reduce hyperactivity, and promote calm behavior. |
| Anti-anxiety & Anti-convulsant | Used for mild sedation, reducing anxiety, and preventing seizures. |
| Recovery from Brain Injuries | Helps in rehabilitation after traumatic brain injury, stroke, or cerebral palsy. |
| Treatment of Developmental Delays | Sometimes prescribed for children with speech delays, motor function disorders, or learning disabilities. |
| Parkinson’s Disease | May be used as part of supportive therapy to improve motor function. |
| Asthenic Conditions | Treats mental fatigue, apathy, irritability, and sleep disturbances. |
Mechanism of Action:
- Enhances GABAergic (γ-aminobutyric acid) transmission in the brain.
- Stabilizes neuronal metabolism.
- Improves energy processes in brain cells.
- Modulates dopamine release and uptake.
- Possesses mild psychostimulant activity without causing overstimulation.
Dosage Forms:
- Tablets
- Syrup (mainly for children)
- Injectable forms (less common)
Trade Names (Examples):
- Pantogam®
- Hopantenic Acid Calcium Salt
- Calcium Homopantothenate
Safety & Side Effects:
- Generally well-tolerated
- Mild drowsiness or sedation
- Rare allergic reactions
- Occasionally gastrointestinal discomfort
Would you like me to provide:
Mechanism of action diagram?
Comparison with other nootropics?
Dosage information?
Clinical study references?