What is Calcium Hopantenate Hemihydrate?

Calcium Hopantenate Hemihydrate is a chemical compound derived from hopantenic acid (also known as pantogamic acid), which is a derivative of pantothenic acid (Vitamin B5). It is commonly used as a nootropic (cognitive enhancer) and neuroprotective agent, primarily in some Eastern European and Asian countries.

Chemical Identity:

Mechanism of Action:

• It acts primarily on the central nervous system.

• Modulates GABA metabolism → GABA-like effect (calming, anti-anxiety, anticonvulsant).

• Enhances glucose uptake and metabolism in neurons.

• Mild stimulant for higher cortical brain functions while reducing excitability in certain nervous system areas.

Medical Uses:

Most commonly used for:

• Improving memory and attention

• Treating developmental delays in children

• Neuroprotective agent after brain injury

• Supporting cognitive function in elderly patients

• Managing behavioral disorders like ADHD or hyperactivity

• Treatment of neurotic conditions, anxiety, or fatigue

Forms Available:

• Tablets

• Syrup (for children)

• Sometimes included in multi-component nootropic supplements

Side Effects:

Generally well-tolerated, but may include:

• Allergic reactions (rare)

• Irritability (in sensitive individuals)

• Sleep disturbances (if taken late in the day)

Availability:

→ Not approved by FDA or EMA (mostly used in Russia, China, and some CIS countries).

→ Often sold under brand names like Pantogam Calcium or Pantocalcin.

How to use Calcium Hopantenate Hemihydrate?

Calcium Hopantenate Hemihydrate — Usage Guide

Calcium Hopantenate Hemihydrate is a nootropic drug commonly used in some countries (especially Russia and Eastern Europe) for its neuroprotective, nootropic, and mild stimulant effects on the central nervous system.

It’s often prescribed for:

• ADHD or hyperactivity in children

• Developmental delays

• Behavioral issues

• Anxiety or irritability

• Memory and concentration problems

• Recovery after brain injuries

• Neuroprotective support in adults

How to Take It:

• Take after meals (to avoid stomach discomfort).

• Swallow with water.

• Usually divided into 2-3 doses per day.

• Duration varies — from a few weeks to several months depending on the condition.

Important Notes:

• Onset is gradual — effects build over days or weeks.

• Usually well-tolerated.

• Not habit-forming.

• Safe for long-term use under supervision.

Possible Side Effects:

• Rare, but may include:

• Sleepiness or mild sedation

• Nausea

• Allergic reactions (rash)

• Irritability (very rarely)

Warning:

• Always consult a healthcare professional before starting.

• Dosage for children should always be individualized.

• Not a replacement for other treatments unless directed by a doctor.