D-Chiro-Inositol (DCI) is one of the nine natural stereoisomers of inositol, a vitamin-like compound often grouped with the B-vitamins. It is found in small amounts in foods and is also produced inside the body.
D-Chiro-Inositol plays key roles in insulin signaling, glucose metabolism, and cellular communication.
Natural Sources
D-Chiro-Inositol occurs naturally (in very small amounts) in:
- Carob
- Buckwheat
- Soy lecithin
- Some fruits and grains
However, most dietary sources contain only tiny quantities, which is why supplements are commonly used.

Functions in the Body
D-Chiro-Inositol is best known for its role as a secondary messenger in insulin pathways. Its key functions include:
1. Insulin Sensitivity
- D-Chiro-Inositol helps cells respond better to insulin, promoting:
- Improved glucose uptake
- Reduced insulin resistance
2. Conversion of Glucose to Glycogen
D-Chiro-Inositol assists in storing glucose as glycogen in muscle and liver cells.
3. Hormone Regulation
In women, D-Chiro-Inositol helps regulate:
- Androgen production
- Ovarian function
It’s often used together with Myo-Inositol for reproductive and metabolic support.
Common Uses
D-Chiro-Inositol supplements are often used for:
- PCOS support (reducing excess androgens, improving ovulation)
- Improving insulin resistance
- Metabolic health
- Blood sugar support
- Supporting healthy ovarian function (especially when paired with Myo-Inositol)
How It Works
D-Chiro-Inositol functions as part of the inositol phosphoglycan (IPG) system.
It helps activate enzymes involved in:
- Glucose uptake
- Glycogen synthesis
- Insulin receptor signaling
Low levels of D-Chiro-Inositol or impaired conversion from Myo-Inositol are associated with metabolic dysfunction.

Forms Available
Typical supplement formats include:
- Capsules
- Powders
- Myo-Inositol + D-Chiro-Inositol blends (often 40:1 ratio used in PCOS research)
Safety & Side Effects
D-Chiro-Inositol is generally well-tolerated.
Possible mild side effects (rare):
- Nausea
- Headache
- Digestive discomfort
D-Chiro-Inositol appears safe for most people, but individuals with medical conditions or who are pregnant should consult a healthcare provider.
