Chemical structure and physical properties of Nicotinamide Riboside

Nicotinamide riboside (NR) is a form of vitamin B3 (niacin) that has gained attention for its potential health benefits, particularly in the context of aging and energy metabolism. Here’s some information about its chemical structure and physical properties:

Chemical Structure:

Nicotinamide riboside has the chemical formula C11H15N2O5 and is a derivative of vitamin B3 (niacin). Its chemical structure consists of:

  • A pyridine ring (a six-membered ring with five carbon atoms and one nitrogen atom).
  • A nicotinamide moiety, which is a substituted amide of pyridine. It contains a carboxamide group (CONH2) attached to the pyridine ring.
  • A ribose sugar molecule, which is a five-carbon sugar (pentose) and is attached to the nicotinamide moiety.

The structure of nicotinamide riboside is often depicted as follows:

Chemical structure and physical properties of Nicotinamide Riboside-Xi'an Lyphar Biotech Co., Ltd

Physical Properties:

  • Solubility: It is water-soluble, which means it can dissolve in water.
  • Melting Point: The melting point of nicotinamide riboside can vary, but it is typically in the range of 128-132°C (262-270°F).
  • Molecular Weight: The molecular weight of nicotinamide riboside is approximately 255.25 g/mol.

Biological Role:

Nicotinamide riboside is a precursor to nicotinamide adenine dinucleotide (NAD+), which is an essential coenzyme involved in various metabolic processes in the body, including energy production. NAD+ plays a crucial role in cellular respiration and is involved in reactions that transfer electrons during the breakdown of glucose and fatty acids. Some studies have suggested that supplementation with nicotinamide riboside may help increase NAD+ levels and potentially have positive effects on aging-related processes and overall health.

It’s important to note that while nicotinamide riboside shows promise, more research is needed to fully understand its mechanisms and long-term effects on human health. Always consult with a healthcare professional before starting any new supplement regimen.