RU58841, also known as PSK-3841 or HMR-3841, is a non-steroidal anti-androgen compound. It is primarily used in scientific research as a topical treatment for androgenetic alopecia (male pattern baldness) and hirsutism (excessive hair growth). Here is some information about its chemical structure and physical properties:
Chemical Structure:
RU58841 has the following chemical structure:
Its IUPAC (International Union of Pure and Applied Chemistry) name is 4-(3-(4-(1,2,4-triazol-1-yl)butyl)-4,4-dimethyl-2,6-dioxocyclohexylidene)methyl)benzoic acid.
Physical Properties:
RU58841 is typically found as a white to off-white powder. Its physical properties include:
Molecular Formula: C17H18N6O6
Molecular Weight: 394.36 g/mol
Melting Point: It doesn’t have a well-defined melting point, as it is usually used in solution form.
Solubility: It is sparingly soluble in water but more soluble in organic solvents like dimethyl sulfoxide (DMSO) or ethanol.
Boiling Point: Not applicable as it decomposes before reaching a boiling point.
RU58841 is known for its anti-androgenic properties, meaning it can block the effects of androgens like testosterone and dihydrotestosterone (DHT) on hair follicles. It does so by binding to the androgen receptors in the hair follicles and preventing the androgens from exerting their effects, which can help slow down or even reverse hair loss in some individuals. However, it’s important to note that its safety and efficacy may vary, and it should only be used under the guidance of a medical professional.
Please be aware that the use of RU58841 and similar compounds is a subject of ongoing research, and its use for hair loss is not approved by regulatory agencies like the FDA for medical treatment. It is primarily used in experimental and research settings. If you are interested in using RU58841 for any purpose, it’s important to consult with a healthcare provider for guidance and to ensure it is safe and appropriate for your specific needs.
Efficacy and effects of RU58841
RU58841 is a non-steroidal anti-androgen compound that has been investigated for its potential use in the treatment of androgenetic alopecia (male pattern baldness) and other androgen-related skin conditions. It is often considered an alternative to more commonly used treatments like finasteride and minoxidil.
Here are some key points about the efficacy and effects of RU58841:
Mechanism of Action: RU58841 works by blocking the binding of dihydrotestosterone (DHT) to androgen receptors in the hair follicles and sebaceous glands. DHT is a hormone that contributes to hair loss in individuals genetically predisposed to androgenetic alopecia.
Hair Growth: Some studies and anecdotal reports suggest that RU58841 may promote hair growth and slow down hair loss in individuals with androgenetic alopecia. It is believed to be effective in reducing the influence of androgens on hair follicles, which can help maintain and improve hair density.
Local Application: RU58841 is typically applied topically, directly to the scalp. This localized application is believed to minimize systemic side effects often associated with oral anti-androgen medications like finasteride.
Side Effects: Since RU58841 is applied topically, it is thought to have fewer systemic side effects compared to orally administered anti-androgen medications. However, there can be local side effects, such as scalp irritation, itching, or redness.
Clinical Evidence: It’s important to note that RU58841 is not as extensively studied as FDA-approved treatments like finasteride and minoxidil. Therefore, the clinical evidence for its efficacy and safety is limited. Much of the information comes from anecdotal reports and smaller-scale studies.
Legality and Availability: RU58841 is not approved by the U.S. Food and Drug Administration (FDA) or other regulatory agencies for the treatment of hair loss. It is often considered a research chemical and is not widely available through conventional medical channels. Users should exercise caution when obtaining and using this compound.
Consult a Healthcare Professional: If you are considering using RU58841 or any other experimental or off-label treatments for hair loss, it’s important to consult with a healthcare professional, preferably a dermatologist or hair loss specialist, to discuss potential benefits and risks.
In summary, RU58841 is a non-steroidal anti-androgen compound that has shown promise in promoting hair growth and preventing hair loss in individuals with androgenetic alopecia. However, it lacks the extensive clinical evidence and regulatory approval of more established treatments. If you are interested in using RU58841 or similar compounds, it is crucial to seek guidance from a healthcare professional and carefully weigh the potential benefits and risks.