Cycloastragenol’s effectiveness, side effects, and caveats

Cycloastragenol is a natural compound derived from the root of the Astragalus membranaceus plant, which has been used in traditional Chinese medicine for its potential health benefits. It is often promoted for its supposed anti-aging and longevity-enhancing properties. However, it’s important to note that while there is some research on cycloastragenol, the available information is limited and not yet fully conclusive.

Cycloastragenol’s effectiveness, side effects, and caveats-Xi'an Lyphar Biotech Co., Ltd


Cycloastragenol’s potential effectiveness is primarily based on its proposed ability to activate an enzyme called telomerase. Telomerase plays a role in maintaining and lengthening telomeres, the protective caps at the ends of chromosomes. Telomeres naturally shorten as cells divide, and this is considered a part of the aging process. Longer telomeres are associated with healthier cells and potential longevity.

Some studies, mainly conducted on animal models and in vitro (test tube) settings, suggest that cycloastragenol might have the ability to increase telomerase activity and lengthen telomeres. However, the translation of these findings to human health and longevity is still uncertain. Clinical trials involving humans are lacking, and the long-term effects and safety of cycloastragenol supplementation are not well-established.

Side Effects:

As of my last knowledge update in September 2021, there hasn’t been a comprehensive assessment of the potential side effects of cycloastragenol in humans. Since there is limited clinical data available, it’s important to exercise caution if considering supplementation. Like any compound, cycloastragenol could potentially have side effects or interactions with other medications and supplements. Common sense dictates that any supplement should be used with care and under the guidance of a healthcare professional.


  • Lack of Human Studies: The most significant caveat is the lack of well-designed, large-scale clinical trials involving humans. While some research has shown promise, it’s essential to have robust human trials to determine the true effectiveness and safety of cycloastragenol.
  • Unregulated Market: The dietary supplement market is not well-regulated in many countries, which means that the quality and purity of cycloastragenol supplements can vary. It’s important to choose products from reputable manufacturers and consult with a healthcare professional before starting any new supplement.
  • Limited Evidence: While there is interest in cycloastragenol’s potential benefits, the evidence base is still developing. Claims about its anti-aging effects should be approached with skepticism until more definitive research is available.
  • Individual Variation: Even if cycloastragenol were to show positive effects in some individuals, it’s important to remember that the response to supplements can vary widely based on factors such as genetics, overall health, and lifestyle.
Cycloastragenol’s effectiveness, side effects, and caveats-Xi'an Lyphar Biotech Co., Ltd

In conclusion, while cycloastragenol holds promise in terms of its potential effects on telomerase activity and telomere lengthening, its effectiveness, side effects, and long-term safety in humans are not yet well-established. If you are considering using cycloastragenol or any other supplement, it’s advisable to consult with a healthcare professional to make an informed decision based on your individual health needs and circumstances.