Effectiveness of Nicotinamide, side effects, and special precautions

Nicotinamide, also known as niacinamide or vitamin B3, is a water-soluble vitamin that is commonly used for various purposes. It has several potential benefits, side effects, and special precautions that you should be aware of:


  • Skin Health: Nicotinamide has been studied extensively for its positive effects on skin health. It is a common ingredient in skincare products and has been shown to help with various skin conditions, including acne, rosacea, and aging-related concerns. Nicotinamide can improve the skin’s barrier function, reduce inflammation, and increase the production of collagen.
  • Pellagra Treatment: Nicotinamide is used to treat and prevent pellagra, a condition caused by a deficiency of vitamin B3. Pellagra can cause symptoms such as dermatitis, diarrhea, and dementia.
  • Migraine Prevention: Some research suggests that nicotinamide may help in preventing migraines, although more studies are needed to confirm this.
  • Cellular Health: Nicotinamide is a precursor to nicotinamide adenine dinucleotide (NAD+), a molecule involved in various cellular processes, including energy production and DNA repair. Some research suggests that nicotinamide supplementation may have potential benefits for overall cellular health.
Effectiveness of Nicotinamide, side effects, and special precautions-Xi'an Lyphar Biotech Co., Ltd

Side Effects:

Nicotinamide is generally considered safe when taken at recommended doses. However, like any supplement or medication, it can have side effects, although they are usually mild. Common side effects may include:

  • Upset stomach
  • Flushing or skin redness (less common than with niacin)
  • Itching or rash (rare)

High doses of nicotinamide can, in rare cases, lead to more serious side effects, including liver problems. If you experience any unusual or severe side effects, you should seek medical attention.

Special Precautions:

  • Allergies: If you are allergic to nicotinamide, niacin, or any other medications, you should avoid nicotinamide supplements.
  • Pregnancy and Breastfeeding: Nicotinamide is generally considered safe when used at recommended doses during pregnancy and breastfeeding. However, you should consult with a healthcare provider before using it, as individual circumstances may vary.
  • Interactions: Nicotinamide can interact with certain medications, including blood thinners and diabetes medications. It’s essential to inform your healthcare provider about all the medications and supplements you are taking to avoid potential interactions.
  • Medical Conditions: If you have liver disease, kidney disease, or other chronic medical conditions, you should consult with a healthcare provider before taking nicotinamide supplements.
  • Dosage: It’s important to follow the recommended dosage instructions on the product label or as prescribed by a healthcare provider. Avoid taking excessively high doses, as this can lead to side effects.

As with any supplement or medication, it’s crucial to consult with a healthcare professional before starting nicotinamide supplementation, especially if you have any underlying medical conditions or are taking other medications. They can provide guidance on the appropriate dosage and monitor for potential side effects or interactions.