Effectiveness, side effects and special considerations of Nattokinase

Nattokinase is an enzyme extracted from natto, a traditional Japanese fermented soybean dish. It has gained attention for its potential health benefits, particularly in cardiovascular health. However, it’s essential to note that while some studies suggest positive effects, more research is needed, and individual responses may vary. Here’s an overview of the effectiveness, side effects, and special considerations associated with nattokinase:


1.Cardiovascular Health:

Blood Clot Prevention: Nattokinase is believed to have fibrinolytic properties, which means it may help prevent and dissolve blood clots. Some studies suggest it could have potential benefits in reducing the risk of thrombosis.

2.Blood Pressure:

Hypertension: There is limited evidence suggesting that nattokinase may contribute to lowering blood pressure, possibly by improving blood flow.

Effectiveness, side effects and special considerations of Nattokinase-Xi'an Lyphar Biotech Co., Ltd

Side Effects:


Soy Allergies: Since nattokinase is derived from soy, individuals with soy allergies should avoid it.

2.Digestive Issues:

Gastrointestinal Discomfort: Some people may experience digestive discomfort or mild gastrointestinal issues, although this is not common.

3.Bleeding Risk:

Blood Thinning: Due to its potential anti-clotting effects, there might be an increased risk of bleeding, especially when taken with other anticoagulant medications. Individuals with bleeding disorders or those on blood-thinning medications should consult a healthcare professional before using nattokinase.

Special Considerations:

1.Pregnancy and Breastfeeding:

Limited Research: There is insufficient research on the safety of nattokinase during pregnancy and breastfeeding, so it’s advisable for pregnant and breastfeeding women to avoid it unless directed otherwise by a healthcare provider.

2.Medication Interactions:

Anticoagulants: Nattokinase may interact with anticoagulant medications, potentially increasing the risk of bleeding. Consult with a healthcare professional before using nattokinase if you are on blood-thinning medications.


Discontinue Before Surgery: Due to its potential anti-clotting effects, individuals scheduled for surgery should discontinue nattokinase use a couple of weeks before the procedure, under the guidance of a healthcare professional.

Effectiveness, side effects and special considerations of Nattokinase-Xi'an Lyphar Biotech Co., Ltd

4.Dosage and Quality:

Varied Products: The quality and potency of nattokinase supplements can vary between brands. It’s crucial to choose a reputable brand and follow the recommended dosage instructions.

While some studies suggest potential benefits of nattokinase, more research is needed to establish its effectiveness and safety conclusively. Individuals considering nattokinase supplementation should consult with a healthcare professional, especially if they have pre-existing medical conditions or are taking medications that may interact with it. Always prioritize a balanced and varied diet, and consult with a healthcare provider before adding any new supplements to your routine.