Effectiveness, side effects, and special precautions of Glycyrrhetinic Acid

Glycyrrhetinic acid is a compound derived from licorice root and is commonly used in cosmetics and skincare products for its various benefits. Here’s an overview of its effectiveness, potential side effects, and special precautions:


Anti-inflammatory: Glycyrrhetinic acid has been shown to possess anti-inflammatory properties, making it beneficial for conditions like eczema, psoriasis, and other inflammatory skin conditions.

Skin brightening: It is often used in skincare products for its ability to inhibit melanin production, leading to a brighter complexion and reduction in hyperpigmentation.

Antioxidant: Glycyrrhetinic acid exhibits antioxidant properties, which can help protect the skin from damage caused by free radicals and environmental stressors.

Wound healing: Some studies suggest that glycyrrhetinic acid may aid in wound healing by promoting collagen synthesis and accelerating the repair process.

Effectiveness, side effects, and special precautions of Glycyrrhetinic Acid-Xi'an Lyphar Biotech Co., Ltd

Side Effects:

Hypertension: Glycyrrhetinic acid can inhibit the enzyme responsible for the breakdown of cortisol, leading to increased cortisol levels in the body. Prolonged elevation of cortisol levels can cause sodium retention and potassium loss, potentially leading to hypertension.

Hypokalemia: Excessive consumption or application of glycyrrhetinic acid can result in hypokalemia, a condition characterized by low potassium levels in the blood. This can lead to symptoms such as muscle weakness, fatigue, and irregular heartbeat.

Hormonal effects: Glycyrrhetinic acid may have hormonal effects, particularly in women. It may interfere with estrogen metabolism and lead to hormonal imbalances in some individuals.

Skin irritation: In some cases, glycyrrhetinic acid can cause skin irritation, especially in individuals with sensitive skin. It is important to perform a patch test before using products containing this ingredient extensively.

Special Precautions:

Pregnancy and breastfeeding: Pregnant and breastfeeding women should exercise caution when using products containing glycyrrhetinic acid, as its hormonal effects may pose risks to maternal and fetal health.

Medical conditions: Individuals with hypertension, heart disease, or hormonal imbalances should consult with a healthcare professional before using products containing glycyrrhetinic acid.

Effectiveness, side effects, and special precautions of Glycyrrhetinic Acid-Xi'an Lyphar Biotech Co., Ltd

Dosage and concentration: Pay attention to the dosage and concentration of glycyrrhetinic acid in skincare products. Higher concentrations may increase the risk of side effects.

Allergic reactions: If you have a known allergy to licorice root or any of its derivatives, avoid using products containing glycyrrhetinic acid to prevent allergic reactions.

As with any skincare ingredient, it’s essential to use products containing glycyrrhetinic acid as directed and to discontinue use if you experience any adverse reactions. Consulting with a dermatologist or healthcare professional can provide personalized advice based on your specific needs and medical history.