Benfotiamine is a synthetic, fat-soluble form of Vitamin B1 (Thiamine) that is used mainly to support nerves + lower “AGEs” (advanced glycation end products).
This is general information only — not personal medical advice.
If you’re on medications (especially diabetes meds, metformin, insulin, or blood thinners), or have medical conditions — ask your clinician first.
Typical ways people use it
| Purpose (common) | Common dose ranges seen in studies |
| Diabetic neuropathy support | 300–600 mg/day (split or single dose) |
| General AGE / glycation lowering support | 150–300 mg/day |
| Thiamine repletion (fat soluble form) | 150–300 mg/day |
How to take it
- You usually take it with food (fat soluble → absorption is good with a meal)
- Once daily is common, or 2× daily split
- It pairs well with alpha-lipoic acid (ALA) in some nerve support protocols — BUT that combo means stronger blood sugar effects → again, talk to clinician.
How fast it works
- Nerve symptom changes can take 4–12 weeks.
- Glycation marker changes (like AGEs) can take months.
Safety / things to know
Most tolerate it well. But:
| watch for | notes |
| low blood sugar (if you’re on glucose-lowering meds) | it can potentiate insulin sensitivity |
| GI upset / nausea | rare — usually from high dose fast |
| pregnant / breastfeeding | not enough high quality data — avoid unless provider says yes |
simple intro schedule (safe conservative)
for an adult with no med conflicts (again: confirm with a clinician):
- Week 1–2: 150 mg daily with a meal
- Week 3+: optionally increase to 300 mg daily if needed
Many people never need above 300 mg/day.
If you want, tell me:
- why you’re interested (what symptom or purpose?)
- what other supplements / meds you are on
- your general health status
I can make you a personalized safe regimen idea (still non-medical) tailored to your goal — nerve pain vs longevity anti-glycation vs energy metabolism → the dose and pairing changes.