Materials and methods of Cocoyl Glutamic Acid


1.Cocoyl Glutamic Acid

Definition: Cocoyl glutamic acid is an amino acid surfactant derived from the reaction of coconut fatty acid and glutamic acid.

Appearance: Typically appears as a white to off-white powder or granules.

Solubility: It is soluble in water and commonly used in aqueous solutions.

pH: Generally used in formulations with a pH range of 5 to 7.

2.Glutamic Acid

Source: Obtained from fermentation processes or synthesized chemically.

Grade: Cosmetic or pharmaceutical grade to ensure purity and safety.

Materials and methods of Cocoyl Glutamic Acid-Xi'an Lyphar Biotech Co., Ltd

3.Coconut Fatty Acid

Source: Derived from coconut oil through hydrolysis.

Composition: A mixture of fatty acids, predominantly lauric acid.

4.Solvents and Reagents

Solvents: Water, ethanol, or other suitable solvents for dissolving and reacting.

Catalysts and pH Adjusters: Hydrochloric acid (HCl), sodium hydroxide (NaOH), and other pH adjusters to maintain the desired pH during synthesis.


1.Preparation of Coconut Fatty Acid

Hydrolysis: Coconut oil is hydrolyzed to release the fatty acids. This can be done using water, steam, or enzymes under controlled conditions.

2.Synthesis of Cocoyl Glutamic Acid

Esterification/Condensation Reaction: The coconut fatty acid reacts with glutamic acid in the presence of a suitable catalyst.

3.Reaction Conditions:

Temperature: The reaction is typically carried out at elevated temperatures (70-90°C).

Catalyst: Acidic or basic catalysts may be used to facilitate the reaction.

Reaction Time: This can vary but usually takes several hours to complete.


Neutralization: The reaction mixture is neutralized to achieve the desired pH.

Extraction: The product is extracted using suitable solvents to separate it from by-products and unreacted materials.

Filtration and Drying: The final product is filtered and dried to obtain Cocoyl Glutamic Acid in its desired form (powder or granules).

Materials and methods of Cocoyl Glutamic Acid-Xi'an Lyphar Biotech Co., Ltd

5.Characterization and Quality Control

Spectroscopic Analysis: Techniques like NMR (Nuclear Magnetic Resonance) and FTIR (Fourier Transform Infrared Spectroscopy) are used to confirm the structure and purity of the product.

Chromatography: HPLC (High-Performance Liquid Chromatography) to determine the purity and identify any impurities.

pH Measurement: The pH of the aqueous solution of the final product is measured to ensure it falls within the desired range.

6.Formulation into End Products

Incorporation into Cosmetics: Cocoyl Glutamic Acid is mixed into formulations like shampoos, facial cleansers, and body washes.

Stability Testing: The formulated products undergo stability testing to ensure long-term effectiveness and safety.

This method ensures the production of high-quality Cocoyl Glutamic Acid suitable for use in various personal care and cosmetic products.