Mechanism of Action of WS-23

WS-23 is a cooling agent commonly used in food, beverages, cosmetics, and vaping products to produce a cooling or “refreshing” sensation. It is a member of the menthol-like cooling agents, but it’s chemically distinct from menthol. Here’s how it works:

  • Activation of TRPM8 Receptors: WS-23 interacts with transient receptor potential cation channel subfamily M member 8 (TRPM8) receptors, which are responsible for the sensation of cold. These receptors are found on sensory neurons in the skin and mucous membranes.
  • Cold Sensation: When WS-23 binds to these receptors, it causes a sensation of coldness, even though the actual temperature of the area has not changed. It essentially tricks the brain into perceiving a cooling effect, similar to how menthol produces a cooling sensation.
  • No Real Temperature Change: Unlike actual cooling agents (like ice or menthol), WS-23 does not physically lower the temperature of the skin or the environment. It simply stimulates the sensory receptors to convey the feeling of coolness.
  • Long-lasting Cooling Effect: One of the notable features of WS-23 is that it provides a more sustained cooling effect compared to other cooling agents like menthol, which can fade more quickly.
Mechanism of Action of WS-23-Xi'an Lyphar Biotech Co., Ltd

It’s also valued for being less pungent and more subtle in its cooling effects, which makes it suitable for a variety of applications where a strong menthol-like aroma might be undesirable.

Basic Information of WS-23

WS-23 (also known as 2,3,3,3-tetramethylcyclopropene-1,2-diol) is a synthetic compound commonly used as a cooling agent in the vaping industry, often to simulate the sensation of a “cool” or “icy” feeling without using menthol. It’s part of a class of chemicals known as “cooling agents,” which produce a mild, refreshing cooling effect when inhaled or applied to the skin.

Key Features of WS-23:

  • Cooling Effect: WS-23 is primarily used for its ability to induce a cooling sensation similar to mint or menthol, but it does not have the same strong minty taste. The cooling effect is generally smoother and less intense than menthol.
  • Usage: It’s commonly found in e-liquids, personal care products like toothpaste and mouthwash, and food products. In vaping, it’s used to create a refreshing and smooth experience.
  • Concentration: The concentration of WS-23 in e-liquids is typically low, ranging from 0.1% to 1% depending on the desired intensity of the cooling effect.
Mechanism of Action of WS-23-Xi'an Lyphar Biotech Co., Ltd
  • Non-Mentholated: Unlike menthol, which has a distinctive mint flavor, WS-23 provides only the cooling sensation without a taste profile, making it ideal for those who want the sensation but without altering the flavor of the vape juice.
  • Safety: WS-23 is generally regarded as safe for consumption and inhalation at the levels typically used in e-liquids and food products. However, as with any substance, excessive exposure can cause irritation in some individuals.
  • Chemistry: It’s a synthetic compound, produced by modifying naturally occurring chemical structures. Its molecular structure is designed to interact with the body’s thermoreceptors, which is why it produces a cooling sensation.

If you’re exploring it for a particular purpose (like in e-liquid formulation or a specific product), let me know if you need more detailed info!