Glutathione exists in both reduced (GSH) and oxidized (GSSG) states. In the reduced state, the thiol group of cysteine is able to donate a reducing equivalent (H++ e−) to other molecules, such as reactive oxygen species to neutralize them, or to protein cysteines to maintain their reduced forms. With donating an electron, glutathione itself becomes reactive and readily reacts with another reactive glutathione to form glutathione disulfide (GSSG). Such a reaction is probable due to the relatively high concentration of glutathione in cells (up to 7 mM in the liver).
Generally, interactions between GSH and other molecules with higher relative electrophilicity deplete GSH levels within the cell. An exception to this case involves the sensitivity of GSH to the electrophilic compound’s relative concentration. In high concentrations, the organic molecule Diethyl maleate fully depleted GSH levels in cells. However, in low concentrations, a minor decrease in cellular GSH levels was followed by a two-fold increase. It is used for the prevention and treatment of tissue and cell damage caused by drugs (such as chemotherapy drugs, antituberculosis drugs, psychiatric drugs, paracetamol, etc.), radiotherapy, alcohol, organic phosphorus, etc. It has a protective effect on liver damage caused by various reasons.
|Other names||Reduced Glutathione|
Under pathological conditions when endogenous GSH reduces, timely exogenous GSH has become to be. Exogenous GSH supplements can prevent and treat related diseases, and maintain a healthy body.
(1) Radiation sickness and radiation safety: radiation, radioactive substances, or because of leukopenia caused by anticancer drugs and other symptoms can play a protective effect.
(2) To protect the liver, detoxification, inactivation of hormones, promote bile acid metabolism and help absorb fat and fat-soluble vitamins digestive tract.
(3) Anti-allergy, or inflammation caused by hypoxemia in patients with systemic or local, can reduce cell damage and promote repair.
(4) To improve the course of certain diseases and symptoms as adjuvant drugs. Such as hepatitis, hemolytic disease, and keratitis, cataract and retinal diseases, such as eye disease and improved vision.
(5) Easy to speed up the metabolism of acids in the excretion of free radicals, which play a beauty skin care, and anti-aging effect.
A.Daily nutraceuticals & Dietary supplement
1. Anti-aging, antioxidant, maintaining skin vigor and luster.
2. Whitening skin: restraining the melanin
3. Improve immunity: enhance immune cells’ function and effectively prevent viruses.
B.Drug treatment and prevention
1. Protect liver: prevention & treatment of liver diseases.
2. Detoxification: drugs and other kinds of poisoning auxiliary treatments, helpful for excreting toxins.
3. Prevention and treatment of eye diseases.
4. Auxiliary treatment of diabetes.
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