Minoxidil, A potent direct-acting peripheral vasodilator (vasodilator agent) that reduces peripheral resistance and produces a fall in blood pressure. Minoxidil It’s approved by the FDA for use in men and women for androgenic alopecia or genetic-based hair loss, also known as male pattern hair loss. It is available over the counter for the treatment of androgenic alopecia, among other baldness treatments, but measurable changes disappear within months after discontinuation of treatment. Its effectiveness has largely been demonstrated in younger men (18 to 41 years of age), the younger the better, and in those with balding in the central (vertex) portion of the scalp.
The principle and mechanism of minoxidil germination：
1: Stimulate the proliferation and differentiation of hair follicle epithelial cells.
2: Promote angiogenesis and increase local blood supply.
3: Open potassium channels.
How does Minoxidil work?
1. It can directly relax the smooth muscles of blood vessels and promote blood flow, thereby helping hair growth;
2. Ability to end the resting period early, extend the growth period, and promote the transformation of the resting period to the growth period;
3. It can stimulate the proliferation of hair follicle cells and promote the transformation of vellus hair to terminal hair;
4. It can promote angiogenesis, increase local blood supply and nutrient supply;
5. It can inhibit the infiltration of T lymphocytes around hair follicles and promote the reopening of closed blood vessels
How to make Minoxidil Solution?
In numerous anti-hair loss and hair growth products, Minoxidil has a significant effect, study shows it is the most commonly used drug in hair loss, 2% and 5% minoxidil solutions are commonly sold in the market. the 2% concentration can be used by both men and women, the 5% concentration is only to be used for male hair loss.
The substances you need to prepare: Minoxidil powder, Medicinal alcohol, propylene glycol, or glycerol. (Propylene glycol can be replaced by glycerol),purified Water.
If the concentration of Minoxidil solution is 5%, that means each ml contains 50mg Minoxidil. The concentration of propylene glycol or glycerol is about 30%, the Medicinal alcohol is about 40%, and Purified Water is about 25%.
Here are some steps for your reference:
1. Please mix propylene glycol with purified water, then heated it.
2. Minoxidil can be added to it at 72°C to 75°C and stirred to dissolve completely and mixed for 15 minutes.
3. Cool the solution to room temperature.
4. Alcohol will be added at about 35℃, then mix it to get transparent or light yellow minoxidil liquid.
Minoxidil solution should be packed in a dark colorbottle because the color of the solution will become yellow if under strong light.
Can Finasteride and Minoxidil be used together?
When we talk about anti-hair loss products, the two frequently mentioned products are minoxidil and finasteride, both of which are widely used to treat male pattern hair loss. They can help prevent hair loss and promote hair growth. If so, what’s the difference between them?
One of the biggest differences between minoxidil and finasteride is their dosage form. Minoxidil is a topical medicine that can be used as a liquid solution or foam. It can be used directly on the scalp to promote hair growth. While Finasteride comes in the form of tablets. It is not applied directly to the scalp but has a more systematic effect on the entire body.
Another is the working mechanism is different. Minoxidil is a vasodilator that expands the blood vessels in the scalp and increases blood flow to the hair follicles. it stimulates hair growth by extending the hair growth cycle. Since minoxidil interrupts the hair growth cycle, it may cause a little more hair loss during the first few months of use. this is a normal side effect, as your hair is replaced by new hair, your hair may become thicker. But Finasteride will lower your DHT levels and prevent DHT from binding to hair follicles. Although minoxidil is more like a hair growth agent, finasteride is a barrier that protects the hair follicles of the scalp from DHT.
Studies show that minoxidil and finasteride are safe to take together. they can be used together to get better effects.
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