A new discovery related to ursodeoxycholic acid

UDCA is short for ursodeoxycholic acid, the main ingredient of ursodeoxycholic acid is ursodeoxycholic acid. Clinically, it is mainly used for cholesterol-type gallstones and bile deficiency fat diarrhea. It is considered to be the most effective anti-gallbladder medicine for treating gallstones and hepatitis.

What is ursodeoxycholic acid used for?

Ursodeoxycholic acid is an organic compound, odorless and bitter. Medically, it is used to increase bile acid secretion and changes bile components, reducing cholesterol and cholesterol ester in bile, which is conducive to gradually dissolving the cholesterol in gallstones.

A new discovery related to ursodeoxycholic acid-Lyphar Biotech Co., Ltd

What is the ursodeoxycholic acid mechanism of action?

The industry’s research on the prevention and treatment of COVID-19 has been promoted in an orderly manner. Recently, some researchers have discovered a kind of ursodeoxycholic acid drug that can close the ACE2 receptor.

A new discovery related to ursodeoxycholic acid-Lyphar Biotech Co., Ltd

It should be noted that the Corona Virus Disease can invade the human body, that is, through the ACE2 receptor, closing the ACE2 receptor also means that the virus is closed to enter the cell’s door. This drug can be used to prevent COVID-19 and new variants of viruses.

How to use ursodeoxycholic acid for the treatment of COVID-19?

In the current background, ursodeoxycholic acid is given the meaning and mission of the new era. Based on its powerful effect, ursodeoxycholic acid may become one of the main drugs for preventing Corona Virus Disease in the future.

First, let’s review the pathogenic mechanism of COVID-19. The virus needs to enter the cell in order to copy it. The surface of the virus, with a key or prying tool-like structure, and the cell receptor are like a specific lock. After entering the human body, COVID-19 is combined with a vascular tensional convertase ACE2, which makes ACE2 structural changes, enters the cells, synthesizes new virus particles, and then penetrates cell walls to infect more cells. At the same time, the body’s immune system moves rapidly, such as macrophages starting to devour viruses, and viruses will also amplify in macrophages. Because COVID-19 is a new type, the body lacks specific neutralized antibodies. In this way, immune cells may be excessively activated, forming cytokine storms, causing severe symptoms and organ failure, and eventually leading to death.

A new discovery related to ursodeoxycholic acid-Lyphar Biotech Co., Ltd

During the research process, scholars accidentally found that there were a large number of Fenol X receptor FXR in the bile duct organs. This receptor can effectively open or close ACE2, and ursodeoxycholic acid can inhibit FXR. Turn off the ACE2 channel. In this way, COVID-19 cannot invade cells. The research team has also built the lung and intestine organ, which confirms that ursodeoxycholic acid ACE2 channels can be closed. Next, external cell culture and hamster tests show that ursodeoxycholic acid can effectively prevent COVID-19 infections.

The study continued, and scholars chose to donate lungs that are not suitable for transplant in the organs. Through the ventilator, the lungs were maintained in vitro, and internal circulation was maintained. The lungs are exposed to COVID-19. The results showed that the lung lobe in injection was not infected, and another lung lobe compared to observation infected with the virus. Subsequently, the research team recruited eight healthy volunteers for experiments. The results showed that after the use of ursodeoxycholic acid treatment, the level of ACE2 in the nasal cells of volunteers decreased. Finally, patients with liver diseases who have been accepted and undergoing ursodeoxycholic acid and who have not accepted ursodeoxycholic acid found that the possibility of COVID-19 or hospitalization is lower. To sum up, rigorous scientific research shows that ursodeoxycholic acid can not only prevent COVID-19 infections but also prevent infected people from developing severe illnesses and have a treatment effect.

A new discovery related to ursodeoxycholic acid-Lyphar Biotech Co., Ltd

The mechanism of the act of ursodeoxycholic acid can inhibit the synthesis of internal cholesterol in the liver, improve the solubility of cholesterol in bile, play a role in dissolving stones and gallbladder, protect the liver, reduce triglyceride content, and inhibit the secretion of digestive enzymes.

What are the ursodeoxycholic acid side effects?

Ursodeoxycholic acid may have side effects in clinical applications, and gastrointestinal symptoms may occur, manifested as diarrhea, nausea, vomiting, abdominal pain, constipation, heart burning, and abdominal discomfort. It may cause allergic reactions, local skin redness, itching, rash, and changes like urticaria. In addition, it may cause patients with dizziness, headache, fatigue, and weakness. In addition, some rare cases may occur. For example, liver function may occur, and the patient may cause abdominal pain in the patient. It should be noted that if the drug is prohibited from being used, patients with acute cholecystitis and cholangitis are prohibited, and this situation must be prohibited by biliary obstruction. Patients with severe liver disease are prohibited. In clinical applications, this drug is generally used for steroidal gallbladder stones, and then bile stasis liver disease, bile reflux gastritis, etc. Ursodeoxycholic acid was used to treat cholecosity liver disease in women during pregnancy. Clinical observation and animal tests showed that ursodeoxycholic acid has no teratogenic effects, so it is a safe medicine. Finally, you need to remind everyone that ursodeoxycholic acid is a prescription medicine

Does ursodeoxycholic acid dissolve gallstones?

A new discovery related to ursodeoxycholic acid-Lyphar Biotech Co., Ltd

Related studies have found that ursodeoxycholic acid can also act on the heart of the heart to form fibrous cells and treat arrhythmia. It is worth noting that the heart is an organ with a relatively large ACE2 content. In addition, studies have also found that ursodeoxycholic acid can enhance the mitochondrial function of the body cells, regulate cell energy metabolism and apoptosis pathway, and is expected to play a potential role in the alleviating mechanism of various types of diseases such as Alzheimer’s disease.

What is the situation of ursodeoxycholic acid raw materials supply?

Ursodeoxycholic acid is a drug that has lifted patent protection. Therefore, you don’t have to worry about expensive drug prices. Lyphar Biotech supply ursodeoxycholic acid raw materials since 2011, now our monthly output is around 450kg, and the assay is more than 99% with the HPLC test method, we also supply relate raw materials such as tauroursodeoxycholic acid(TUDCA)deoxycholic acid;chenodeoxycholic acid; Taurochenodeoxycholic acid(TCDCA) and so on, if any questions or demands of ursodeoxycholic acid just contact with us freely.