Origin, properties and introduction of Poloxamer 407

Poloxamer 407, also known by its chemical name, Pluronic F127, is a nonionic block copolymer surfactant that belongs to the class of polyoxyethylene-polyoxypropylene polymers. It is used in a wide range of pharmaceutical, cosmetic, and industrial applications due to its unique properties. Here is some information about its origin, properties, and introduction:

Poloxamer 407 is part of the Pluronic family of polymers, which are proprietary products of BASF Corporation. BASF is a large multinational chemical company that produces a variety of chemicals and polymers for industrial and pharmaceutical use. Poloxamer 407 was developed and is marketed by BASF under the trade name Pluronic F127.

Poloxamer 407

Poloxamer 407 is known for its amphiphilic nature, which means it has both hydrophilic (water-attracting) and hydrophobic (water-repelling) segments. This unique structure gives it several important properties:

Solubility: Poloxamer 407 is highly soluble in both water and organic solvents, making it a versatile material for various applications.

Temperature-Responsive: It is thermoresponsive, which means its properties can change with temperature. It forms a gel at low temperatures and becomes a liquid at higher temperatures. This property is particularly useful in the pharmaceutical and medical fields, where it can be used to create temperature-sensitive drug delivery systems.

Nonionic: It is nonionic, which means it does not carry an electric charge in solution. This makes it less likely to interact with charged molecules and is compatible with a wide range of drugs and other compounds.

Biocompatible: Poloxamer 407 is generally considered safe for use in pharmaceuticals and cosmetics. It is used in various medical and pharmaceutical applications, such as drug delivery and formulations.

Poloxamer 407 was introduced into various industries due to its versatility and unique properties:

Pharmaceutical Applications: Poloxamer 407 is commonly used as a solubilizing agent in drug formulations and as a component in controlled-release drug delivery systems. It can improve the bioavailability of poorly water-soluble drugs.

Cosmetic Applications: In cosmetics, it is used as an emulsifier, stabilizer, and thickening agent in creams, lotions, and other personal care products.

Industrial Uses: Poloxamer 407 is also used in various industrial processes, such as in the formulation of coatings, detergents, and other chemical products.

Medical Applications: It has been employed in medical applications, including as a vehicle for oral and topical medications, and in medical devices.

Poloxamer 407’s unique properties have made it a valuable ingredient in many different fields, and its biocompatibility has further increased its popularity in the pharmaceutical and medical industries, particularly for drug delivery systems and other applications where precise control over solubility and temperature sensitivity is essential.