Poloxamer 407 Effectiveness, side effects, and special considerations

Poloxamer 407, also known by the brand name Pluronic F127, is a nonionic surfactant that belongs to a class of chemicals called poloxamers. It is often used in the pharmaceutical and medical industries, as well as in other applications, such as cosmetics and food. Poloxamer 407 has a variety of uses and can be effective for different purposes, but it’s essential to consider its effectiveness, potential side effects, and special considerations when using it.


Solubilization: Poloxamer 407 is often used as a solubilizing agent for poorly water-soluble drugs. It can improve the solubility and bioavailability of certain drugs, making them more effective when administered orally or through other routes.

Stabilization: Poloxamer 407 is used in pharmaceuticals to stabilize drug formulations and prevent the precipitation or aggregation of active ingredients, which can lead to inconsistent dosing.

Topical Applications: It is used in various topical formulations like creams and ointments to enhance drug absorption through the skin and improve the texture of the product.

Poloxamer 407 Effectiveness, side effects, and special considerations-Xi'an Lyphar Biotech Co., Ltd

Side Effects:

Gastrointestinal Disturbances: When ingested, Poloxamer 407 may cause gastrointestinal side effects such as diarrhea, nausea, or abdominal discomfort.

Allergic Reactions: Some individuals may be hypersensitive to poloxamers and could experience allergic reactions like skin rashes or itching.

Eye and Skin Irritation: Avoid contact with eyes and skin, as it can lead to irritation. If contact occurs, rinse with water immediately.

Cardiovascular Effects: There have been reports of potential cardiovascular effects when Poloxamer 407 is used at high concentrations. However, this is more relevant to animal studies and less so in clinical practice.

Pulmonary Effects: Inhalation of poloxamer dust or aerosols may lead to respiratory irritation and bronchoconstriction in some individuals.

Special Considerations:

Dosage: Always use poloxamer 407 as per the recommended dosage and guidelines provided by the manufacturer or a healthcare professional. Overuse or misuse can lead to adverse effects.

Administration Route: Depending on the specific application, poloxamer 407 may be administered orally, topically, or by other routes. Ensure that you are following the appropriate administration guidelines.

Allergies: Individuals with a known allergy to poloxamers should avoid products containing this ingredient and inform healthcare providers about their sensitivity.

Storage: Store products containing poloxamer 407 according to the manufacturer’s recommendations, and keep them out of reach of children.

Regulatory Approval: Check if the use of poloxamer 407 is regulated or approved for your intended application. In pharmaceuticals, it should comply with relevant regulatory standards.

It’s important to note that the specific application and concentration of poloxamer 407 will determine its safety and effectiveness. Always consult with a healthcare professional or the product manufacturer when using poloxamer-containing products, especially if you have any concerns about its use or potential side effects.