NMN

Dietary Supplement NMN Nicotinamide Mononucleotide (NMN and β-NMN) is a nucleotide derived from ribose and nicotinamide. A long-term study indicates that NMN can slow down the physiologic decline in aging.

Beta-Nicotinamide Mononucleotide NMN belongs to Vitamin B, it can be naturally synthesized in cells, and can also be derived from a variety of foods, including broccoli, cabbage, cucumber, edamame, avocado and the like. In humans, NMN is a precursor of synthetic NAD+, and its physiological function is mainly manifested by increasing NAD+ levels.

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Description

NMN-Xi'an Lyphar Biotech Co., Ltd

Product NameNMN
Other namesNicotinamide Mononucleotide, β-Nicotinamide Mononucleotide,β-NMN
CAS No1094-61-7
StorageStore at Room Temperature
SampleAvailable
Package
1kg/bag ,25kg/bag;25kg/drum; customize as customer’s equirements.
Transit
Fedex, TNT,DHL,EMS,and so on.
Shipping port
Shanghai/Tianjin/Dalian/Beijing/Xi’an
Lead Time
1-2 working days upon received the payment
For mass orders, it will be delivered by air or sea.
Depending on your location, please allow 1-5 business days for your order to arrive.
For small order, please expect 3-7 days by UPS DHL EMS.
For mass order, please allow 5-8 days by Air, 15-30 days by Sea.

What is NMN (Nicotinamide Mononucleotide) Supplement?

NMN (Nicotinamide Mononucleotide) is a nucleotide molecule and a derivative of vitamin B3, also known as niacin[1]. Its structure consists of nicotinamide, ribose, and a phosphate group. Enzymes use NMN to produce NAD (Nicotinamide Adenine Dinucleotide), a crucial coenzyme involved in various cellular processes[2]. As NMN helps generate more NAD, many people take NMN supplements to obtain potential health benefits[3].

How NMN Works

NMN is an intermediate molecule made in the conversion of both nicotinamide and NR (Nicotinamide Riboside) to NAD[2]. When consumed through diet or supplementation, NMN must be converted to NR before entering the cell[2]. Once inside the cell, NR is converted back to NMN and subsequently to NAD[2].

Comparison with NR

Both NMN and NR are precursors to NAD, and they are often compared as anti-aging supplements[3]. NMN is more stable than NR, which is quickly degraded in the bloodstream[3]. Some users report that NMN supplements work better for them than NR supplements, claiming increased energy and vitality[3]. However, it is essential to note that individual experiences may vary, and more research is needed to determine the optimal supplement for each person.

Lyphar and NMN Supplements

Lyphar, a reputable brand in the health supplement industry, offers high-quality NMN supplements to customers seeking potential health benefits. By choosing Lyphar as your NMN supplement provider, you can trust the quality and reliability of the products you receive.

NMN-Xi'an Lyphar Biotech Co., Ltd

Production method comparison:

Semi-Fermentation

Synthesize Niacinamide ribose chloride first, and then produce it into NMN by fermentation.

 

Disadvantages: Enzyme protein impurities that are harmful to the human body will be produced during the production process, and the enzyme protein impurities must be strictly controlled.

 

Advantages: The purity is slightly higher than the purity of the synthetic method.

Synthetic

 

Beta-Nicotinamide Mononucleotide is chemically synthesized from beginning to end

 

Disadvantages: Genotoxic impurities are produced and solvent remains.

Advantages: All impurities are very clear at a glance,  They can be tested by HPLC.

Difference between NAD, NR and NMN:

  • NAD+ is an important coenzyme in the mitochondria for aerobic oxidation and metabolism of the tricarboxylic acid cycle to generate energy   molecular ATP, so that the three types of nutrients obtained by the human body: sugar, fat and protein, are transformed into the energy required by the human body. However, due to its large molecular weight, it is difficult for NAD+ to penetrate the cell membrane and enter the cell, so it cannot be directly taken up.
  • Most of the oral NR is not converted into NMN but is digested into NAM, failing to bypass the restriction of the rate-limiting enzyme NAMPT in the salvage synthesis pathway, and the ability to supplement NAD+ is limited.
  • NMN bypasses the bottleneck of the NAMPT rate-limiting enzyme and can quickly replenish NAD+ in the body, which is the best and ideal supplement method. NMN can quickly enter the blood within 10 minutes, and after 30 minutes it is absorbed by the organs of the body and converted into NAD+, which can quickly replenish NAD+ in the body.

Lyphar NMN Supplement Benefits

Energy Metabolism Support – Research suggests that NMN can promote energy production, especially for older individuals[1].

Healthy Aging Support – Studies indicate that NMN can promote DNA repair and support Sirtuin genes associated with healthy aging and longevity[1].

NAD+ Production Support – NMN has oral bioavailability and supports NAD+ production in the liver and muscle tissues[1].

Made in the China – -Lyphar’s NMN powder is manufactured in China and undergoes purity and potency testing[2].

Description

Nicotinamide Mononucleotide (NMN) is a naturally occurring compound found in small amounts in the human body and certain foods. NMN has oral bioavailability and can support NAD+ levels in the liver and muscle tissues when taken orally[1]. Recent research suggests that NMN may support cardiovascular health, energy production, cognitive health, and retinal and skeletal health[1]. A particularly interesting finding in NMN research is its ability to promote DNA repair and support the activation of SIRTUIN genes, which are believed to play a role in healthy aging[1].

Recommended Dosage

The general recommended dosage of Nicotinamide Mononucleotide is 250-1500 mg per day. Lyphar’s NMN product contains 30 grams of NMN, making a daily 1-gram dosage convenient. It is not advised to take the entire day’s dosage at once but rather divide it into many smaller doses, taken every 1.5-2 hours. Due to NMN’s short half-life, using it this way will result in elevated NAD+ levels throughout the day. If taking a total daily dosage of 1 gram, it is recommended to divide it into approximately 8 doses, taking 125 mg each time, spaced about 1.5 hours apart[1].

Side Effects

Although NMN is a relatively new supplement and research is ongoing, studies conducted so far indicate that it is very safe and non-toxic[1]. Side effects are rare but occasionally include itching, dizziness, sweating, and nausea[1]. Consult your doctor before taking NMN.

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NMN-Xi'an Lyphar Biotech Co., Ltd

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NMN-Xi'an Lyphar Biotech Co., Ltd

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