Ursodeoxycholic Acid UDCA promotes the secretion of endogenous bile acids and reduces reabsorption.
- Cytoprotective effect: Ursodeoxycholic AcidUDCA conjugate significantly reduced the cytolysis of hepatocytes induced by hydrophobic bile acid and reduced apoptosis induced by toxic bile acid in cultured murine and human hepatocytes.
- Membrane stabilization: Ursodeoxycholic AcidUDCA can prevent bile acid-induced changes in mitochondrial membrane permeability, which means it can prevent toxic bile acid-induced damage to the mitochondrial membrane, basement membrane and small bile duct membrane through membrane stabilization.
- Antioxidant effect: Ursodeoxycholic AcidUDCA can inhibit the activation of blastocytes induced by toxic bile acids, and increase the level of glutathione and thiol-containing protein in hepatocytes to prevent the oxidative damage of hepatocytes.
- Immunomodulatory effects: Ursodeoxycholic AcidUDCA inhibits indirectly by reducing the stimulatory impact of hydrophobic bile acids and directly inhibits the expression of histocompatibility complex (MHC) class I and class II genes by activating glucocorticoid receptors.
- Ursodeoxycholic AcidUDCA could reduce SARS-Cov-2 entry into cells, which means it can be anti-Covid-19 to some extent, as reported by NATURE recently.
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