UDCA powder
Ursodeoxycholic Acid, whose short name is UDCA, is the 7-beta isomer of goose deoxycholic acid (the primary bile acid in normal bile). It is a white powder; odorless, bitter taste. It is soluble in ethanol, glacial acetic acid and sodium hydroxide test solution, and insoluble in chloroform.
Description
| Product name | Ursodeoxycholic Acid |
| Other name | UDCA |
| CAS | 83-49-8 |
| EINECS No | 201-483-2 |
| MF | C24H39O4 |
| Purity | 98%+ |
| Appearance | White powder |
Ursodeoxycholic Acid UDCA promotes the secretion of endogenous bile acids and reduces reabsorption.
- Cytoprotective effect: Ursodeoxycholic AcidUDCA conjugate significantly reduced the cytolysis of hepatocytes induced by hydrophobic bile acid and reduced apoptosis induced by toxic bile acid in cultured murine and human hepatocytes.
- Membrane stabilization: Ursodeoxycholic AcidUDCA can prevent bile acid-induced changes in mitochondrial membrane permeability, which means it can prevent toxic bile acid-induced damage to the mitochondrial membrane, basement membrane and small bile duct membrane through membrane stabilization.
- Antioxidant effect: Ursodeoxycholic AcidUDCA can inhibit the activation of blastocytes induced by toxic bile acids, and increase the level of glutathione and thiol-containing protein in hepatocytes to prevent the oxidative damage of hepatocytes.
- Immunomodulatory effects: Ursodeoxycholic AcidUDCA inhibits indirectly by reducing the stimulatory impact of hydrophobic bile acids and directly inhibits the expression of histocompatibility complex (MHC) class I and class II genes by activating glucocorticoid receptors.
- Ursodeoxycholic AcidUDCA could reduce SARS-Cov-2 entry into cells, which means it can be anti-Covid-19 to some extent, as reported by NATURE recently.
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