The difference between the Chitosan Oligosaccharide and Chitosan

Chitosan and chitosan oligosaccharide are both derived from chitin, a natural biopolymer found in the shells of crustaceans like shrimp and crabs. They have different molecular structures and properties, leading to different applications and potential benefits.

The difference between the Chitosan Oligosaccharide and Chitosan-Xi'an Lyphar Biotech Co., Ltd


  • Chitosan is a linear polysaccharide composed of randomly distributed β-(1→4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine (acetylated unit) units.
  • It has a larger molecular size compared to chitosan oligosaccharide.
  • Chitosan is known for its positive charge due to the presence of amino groups. This property makes it useful in various applications such as water treatment, wound healing, and drug delivery.
  • It has the ability to bind to fats and bile acids, potentially aiding in weight management and lowering cholesterol levels.
  • Chitosan has been studied for its antimicrobial and antioxidant properties.
  • Due to its larger molecular size, chitosan may have a higher viscosity, making it suitable for applications requiring gelling or thickening.

Chitosan Oligosaccharide:

  • Chitosan oligosaccharide is a shorter-chain derivative of chitosan, resulting from the hydrolysis or enzymatic degradation of chitosan.
  • It consists of a smaller number of glucosamine and N-acetylglucosamine units compared to chitosan.
  • Chitosan oligosaccharide often retains some of the beneficial properties of chitosan, such as its positive charge and potential health benefits, but with some differences.
  • It is generally more water-soluble and easier to absorb than chitosan due to its smaller molecular size.
  • Chitosan oligosaccharide has been studied for its potential health-promoting effects, including immune system modulation, antioxidant activity, and potential prebiotic effects on gut health.
  • It is often used in dietary supplements, functional foods, and cosmetic products.

In summary, chitosan and chitosan oligosaccharide are related compounds with different molecular sizes and properties. Chitosan is a larger polysaccharide with a positive charge, while chitosan oligosaccharide is a smaller-chain derivative with similar potential benefits, increased solubility, and enhanced bioavailability. Their applications can overlap, but they may be preferred in different contexts based on their specific characteristics.