SLU-PP-332 is an experimental synthetic small molecule developed through research associated with Saint Louis University and the Burris laboratory. It was designed as an agonist of the three estrogen-related receptors: ERRα (ESRRA) ERRβ (ESRRB) ERRγ (ESRRG) It has attracted attention…
SLU-PP-332 is an experimental small-molecule agonist of the estrogen-related receptors ERRα, ERRβ, and ERRγ. It is often described as an “exercise mimetic” because it activates metabolic programs normally stimulated by aerobic exercise. However, as of 2026, the evidence remains preclinical—primarily…
SLU-PP-332 is a synthetic pan-estrogen-related receptor (ERRα/ERRβ/ERRγ) agonist. ERRs cooperate with metabolic transcriptional programs involving PGC-1α and regulate mitochondrial oxidative metabolism. 1. Improves glucose tolerance in obese mice In diet-induced-obesity mouse models, SLU-PP-332 treatment was associated with improved glucose metabolism,…
SLU-PP-332 is a synthetic estrogen-related receptor (ERR) α/β/γ agonist and experimental “exercise mimetic.” Its strongest activity is toward ERRα, a nuclear receptor that regulates mitochondrial metabolism, oxidative muscle function, and exercise-responsive gene expression. Importantly, the evidence for its efficacy is…
SLU-PP-332 is a synthetic small-molecule pan-estrogen-related receptor (ERRα/ERRβ/ERRγ) agonist developed as an experimental “exercise mimetic.” It is a research compound, not an approved medicine or dietary supplement. Recent analytical work has established LC-HRMS/MS methods for identifying the parent compound and…
SLU-PP-332 is a synthetic small-molecule agonist of the estrogen-related receptors (ERRs)—a family of orphan nuclear receptors involved in regulating mitochondrial activity, oxidative metabolism, fatty-acid utilization, and exercise-responsive gene expression. It is particularly notable because it activates ERRα, ERRβ, and ERRγ,…
SLU-PP-332 is a synthetic small-molecule agonist of estrogen-related receptors (ERRα, ERRβ, and ERRγ). It is primarily a research compound, not an approved drug or dietary supplement. Its main value is as a tool for studying exercise-like metabolic adaptations. 1. Exercise-mimetic…
SLU-PP-332 is a synthetic agonist of the estrogen-related receptors (ERRs), especially ERRα. These are nuclear receptors that regulate genes involved in mitochondrial energy production, fatty-acid oxidation, oxidative phosphorylation, and exercise adaptation. Importantly, despite the name, ERRs are not classical estrogen…
SLU-PP-332 appears to have potentially favorable effects on liver fat and systemic lipid metabolism in mice, but the evidence is still preclinical. Importantly, SLU-PP-332 is an ERRα/β/γ agonist, not a PPAR agonist, so PPAR findings should be treated as mechanistic…