Natamycin is a kind of polyolefin macrolide antifungal agent. Its molecule is an active cyclic tetraene compound, containing more than 3 crystals of water. Its appearance is white (or cream color). It is a colorless and tasteless crystalline powder. Its molecular formula is C33H47NO13, and its molecular weight is 665.73. Slightly soluble in water and methanol, soluble in dilute acid, glacial acetic acid and dimethylformamide, and insoluble in most organic solvents. When the pH value is higher than 9 or lower than 3, its solubility will be improved, and it is very stable in the PH range of most foods. Natamycin has specific heat treatment resistance, is relatively stable in the dry state, and can withstand transient high temperatures (100 ℃); However, due to its ring chemical structure and its sensitivity to ultraviolet radiation, it should not contact sunlight. The stability of natamycin activity is affected by PH value, temperature, light intensity, oxidants and heavy metals, so the product should avoid contact with oxides and hydrogen sulfide compounds.
Natamycin buys a natural, broad-spectrum, efficient and safe filamentous fungal inhibitor of yeast and mold. It can not only inhibit fungi but also prevent the production of mycotoxins. Natamycin is harmless to the human body and difficult to be absorbed by the human digestive tract, and it is difficult for microorganisms to develop resistance to it. At the same time, because of its low solubility, it is usually used for food surface anti-corrosion. Natamycin is the only antifungal microbial preservative in the world, mainly used in the production and preservation of dairy products, meat products, fermented wine, beverages and other foods.
Natamycin production method
Natamycin suppliers produce Natamycin by fermentation with Streptomycesnatalensls and StrePtomycesgilvosPoreu.
Cheese, meat products, broth, ham, Cantonese style moon cakes, pastry surfaces, etc., spray or soak with 200-300mg/kg suspension. The residue shall be less than 10mg/kg
In June 1982, the US FDA officially approved that natamycin can be used as a food preservative. In 1996, China Food Additives Standardization Technical Committee officially approved Natamycin as a food preservative. The FAO/WHO Joint Expert Committee on Food Additives has stipulated that the human body can unconditionally accept Natamycin 0.3mg per kg of body weight per day. JECFA/EC also authorizes approval.