Over 100 trade name drugs that contain the active ingredient Minoxidil are available internationally.
Minoxidil, a potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. Minoxidil, it’s approved by the FDA for use in men and women for androgenic alopecia or genetic-based hair loss, also known as male pattern hair loss.
It is available over the counter for treatment of androgenic alopecia, among other baldness treatments, but measurable changes disappear within months after discontinuation of treatment. Its effectiveness has largely been demonstrated in younger men (18 to 41 years of age), the younger the better, and in those with balding in the central (vertex) portion of the scalp.
Minoxidil is a potassium channel agonist. It contains the chemical structure of nitric oxide), a blood vessel dilator, and may be a nitric oxide agonist. This appears to explain its vasodilatory effects, but may also be linked to minoxidil’s ability to stimulate hair growth and treat hair loss. Since minoxidil is a nitric oxide-related compound, it was suspected to act via activation of guanylate cyclase, an enzyme involved in vasodilation.
Minoxidil is clinically used as a potassium channel opener, which is a blood pressure lowering drug for refractory, primary or renal hypertension.
But in the treatment of high blood pressure, minoxidil can make the hair (beard) grow longer and thicker. Therefore, it has been developed and applied as a drug for the treatment of male pattern baldness. The opening of potassium channels is an important step in regulating hair growth. Minoxidil can increase the permeability of potassium ions, prevent calcium ions from flowing into human cells, and increase the supply of blood to make hair grow and accelerate hair growth. Growth phase transformation.
- How Minoxidil Works?
- How long before Minoxidil Start working?
- What are the side effects of minoxidil?
- How do I know if Minoxidil is working?
- Who gets the best results from Minoxidil?
How Minoxidil Works?
Hair goes through several phases as it grows. At first, it enters into an anagen phase. This is the period in which the hair grows. After this, it goes into the catagen and telogen phases, in which it shrinks and detaches from the follicle and is replaced by a new hair.
Finally, each hair enters into the exogen phase, during which it falls out from your scalp and is replaced by the new hair.
Minoxidil can also help strengthen existing hair and promote their growth by increasing the blood and nutrient supply to the hair follicles.
Minoxidil helps promote hair regrowth in 4 ways:
- Reverse follicle miniaturization.
- Increases blood flow around the hair follicles.
- Stimulates the movement of hair follicles into the anagen phase.
- Prolong each follicle growth stage.
How long before Minoxidil Start working?
Minoxidil is a hair loss and hair regrowth treatment that’s widely used to treat male pattern hair loss. Like most hair loss treatments, minoxidil begins working immediately but can take several months to produce noticeable results.
Minoxidil works by creating an ideal growth environment for your existing hair follicles.
What are the side effects of minoxidil?
Because minoxidil is a widely used and thoroughly tested drug, its side effects are well known among doctors and researchers.
Depending on the formulation, the most common side effect of minoxidil is skin irritation at or near the application site. In some cases, minoxidil users may experience a rash or a slight burning sensation after using minoxidil spray or foam.
This may be a reaction to minoxidil itself or some substances commonly used in minoxidil preparations. Many minoxidil products contain propylene glycol and alcohol, which can cause rashes and irritation when used topically.
Millions of men around the world use minoxidil daily to prevent hair loss and improve hair growth.
Overall, side effects are rare, and minoxidil is considered one of the safest hair loss treatments on the market today.
How do I know if Minoxidil is working?
Because minoxidil is a topical application applied to the scalp, the treatment begins to work immediately. But that doesn’t mean you’ll see results right away. The process is a long game. You will need to continue using the therapy daily before seeing visible results in about 3-6 months.
If you have been using minoxidil for 6-9 months with no results, this product may not be right for you. This may be because your hair follicles lack the enzymes needed to convert and activate active ingredients.
If it works, minoxidil works on a biological level by dilating blood vessels in the scalp to alter the scalp environment and hair growth cycle. Your hair goes through several stages, first entering the anagen phase, then shrinking and shedding from the follicle to make way for new hair.
Who gets the best results from Minoxidil?
Apply minoxidil to the scalp to aid hair growth and prevent hair loss due to hair loss in men or women. This is the most common type of hair loss and is prevalent in families.
Minoxidil is best for people with hereditary hair loss at the top of the scalp (back of the head, under the top of the head) or women with general thinning of hair on the top of the scalp.
Minoxidil is most effective for people who start using it when they show signs of hair loss. This does not help someone who is already completely bald.
All in all, while minoxidil has been shown to be effective in regenerating hair, it is not suitable for everyone and for all types of hair loss.
It is FDA-approved to help hair growth in men with hair loss and women with thinning hair. But it has been used for other types of hair loss, although you should consult your doctor before using it.
If it works for you, you probably won’t grow all your hair. It usually has to be used continuously if the result is to be maintained.
Current research suggests that minoxidil can directly stimulate the proliferation and differentiation of hair follicle epithelial cells; promote blood vessel formation, increase local blood flow; open potassium channels; and transform hair follicles from resting phase to growth phase. Systemic absorption of topical minoxidil is minimal. Sufficient clinical trials have confirmed that minoxidil has a good effect on androgenetic alopecia and alopecia areata, but long-term medication is required to maintain the effect. The shorter the period of hair loss and the smaller the area, the better the prognosis. High concentration is more effective than low concentration, but it also causes more local adverse reactions. Large-scale clinical trials have confirmed that topical minoxidil is feasible for the treatment of hair loss. If you want to know more about the instructions of Minoxidil, you can check it through this link.
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