Origin, Properties and Introduction of 5-Amino-1MQ Iodide

5-Amino-1MQ Iodide is a chemical compound with applications in biomedical research, particularly in the study of metabolic disorders and weight management. Let’s break down its origin, properties, and introduction in more detail:

Origin of 5-Amino-1MQ Iodide:

The compound 5-Amino-1MQ Iodide (often referred to as 5-Amino-1-methylquinazoline) and its iodide form have been studied in recent years for their potential impact on the inhibition of certain enzymes and pathways involved in metabolic regulation. The specific iodide salt form is often used to enhance the solubility of the compound, making it more suitable for experimental use.

The original work on 5-Amino-1MQ Iodide is linked to its role in inhibiting the activity of NNMT (Nicotinamide N-methyltransferase), an enzyme involved in the metabolism of nicotinamide, which is part of the vitamin B3 pathway. NNMT plays a role in regulating cellular metabolism and energy expenditure, and inhibiting this enzyme has been shown to have potential therapeutic effects in conditions like obesity, metabolic syndrome, and certain cancers.

Origin, Properties and Introduction of 5-Amino-1MQ Iodide-Xi'an Lyphar Biotech Co., Ltd

Properties of 5-Amino-1MQ Iodide:

1. Chemical Composition:

    • 5-Amino-1MQ Iodide is derived from quinazoline, a heterocyclic aromatic compound. The compound has an amino group (NH2) attached to the quinazoline structure, which is key to its biological activity.
    • In its iodide form, it is typically paired with iodide (I-) to form a more stable and soluble salt.

    2. Molecular Structure:

      • The compound contains a quinazoline ring system with an amino group and a methyl group at specific positions. The iodide (I-) anion helps stabilize the structure and improves its pharmacological properties, particularly its solubility in aqueous solutions.

      3. Solubility:

        • As an iodide salt, 5-Amino-1MQ Iodide is more soluble in water and solvents than its base form, making it easier to administer in biological studies.

        4. Bioactivity:

          • 5-Amino-1MQ Iodide is recognized for its ability to inhibit NNMT (Nicotinamide N-methyltransferase). By blocking this enzyme, it is hypothesized to affect cellular metabolism, energy production, and potentially fat storage. It can lead to reduced fat accumulation and improved metabolic functions, which is of interest in obesity and weight management studies.
          Origin, Properties and Introduction of 5-Amino-1MQ Iodide-Xi'an Lyphar Biotech Co., Ltd

          Introduction of 5-Amino-1MQ Iodide:

          5-Amino-1MQ Iodide was introduced primarily in the context of research aimed at understanding how metabolic processes can be modulated to treat conditions like obesity and metabolic diseases. The compound’s ability to target NNMT suggests that it could have broad applications in controlling metabolic pathways, which has piqued interest in the pharmaceutical and nutraceutical fields.

          Studies have suggested that NNMT inhibition could lead to improved fat oxidation and better glucose metabolism, making this compound an attractive candidate for weight loss and metabolic health. Additionally, there are indications that 5-Amino-1MQ Iodide could potentially be developed for the treatment of metabolic disorders or even certain cancers, although more research is necessary to confirm these potential benefits.

          In summary, 5-Amino-1MQ Iodide is an experimental compound with significant potential in regulating metabolism, particularly through the inhibition of the NNMT enzyme. It has been introduced in scientific research as a promising tool in understanding and managing metabolic health.