Origin of Benfotiamine Benfotiamine is a synthetic S-acyl derivative of thiamine (vitamin B1). It was developed in Japan in the 1960s–1970s as part of a research trend to create lipid-soluble thiamine analogs that could bypass poor intestinal absorption of regular…
Benfotiamine is a synthetic, fat-soluble precursor of Vitamin B1 with high bioavailability. Taken orally, benfotiamine produces supra-physiological blood levels of the active coenzyme form of thiamine. 1. Chemical Nature Vitamin B1 (Thiamine): Benfotiamine: 2. Absorption & Bioavailability Vitamin B1: Benfotiamine:…
Benfotiamine is a fat-soluble derivative of vitamin B1 (thiamine). Its main medical relevance for diabetes is prevention of biochemical damage caused by chronic high blood sugar. Mechanisms (main understood actions) Chronic hyperglycemia → increases formation of “AGEs” (Advanced Glycation End…
Benfotiamine, a lipid-soluble derivative of vitamin B1 (thiamine), has several clinical applications, primarily due to its ability to increase intracellular thiamine levels and reduce advanced glycation end products (AGEs) and oxidative stress. Here’s a detailed overview: 1. Diabetic Complications Benfotiamine…
Benfotiamine (S-benzoylthiamine-O-monophosphate) is a synthetic, lipid-soluble thiamine derivative. Chemical structure of Benfotiamine Formula: C₁₉H₂₃N₄O₆PS Exact mass: ~470.45 g/mol IUPAC: S-benzoylthiamine O-monophosphate The benzoyl group is the key — this blocks water-loving ionic sites → this is why Benfotiamine is fat-soluble (standard thiamine is…
Benfotiamine (rINN, or S-benzoylthiamine O-monophosphate) is a synthetic, fat-soluble, S-acyl derivative of thiamine (vitamin B1) that is approved in some countries as a medication or dietary supplement to treat diabetic sensorimotor polyneuropathy. Benfotiamine was developed in the late 1950s in…
Benfotiamine is a synthetic, fat-soluble form of Vitamin B1 (Thiamine) that is used mainly to support nerves + lower “AGEs” (advanced glycation end products). This is general information only — not personal medical advice. If you’re on medications (especially diabetes…
Benfotiamine is basically a synthetic fat-soluble derivative of vitamin B1 (thiamine). To be more precise: Parent / basic ingredient: → Thiamine (Vitamin B1) Benfotiamine is chemically: So the core backbone is thiamine, but modified with a benzoate (benzoyl) group and…
Benfotiamine = a synthetic lipid-soluble derivative of thiamine (vitamin B1). Different from regular thiamine because it gets into cells more efficiently and more into the “transketolase pathway” → less harmful AGEs. Main evidence-based application zones Application Why it’s relevant Human…